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EC number: 202-509-5
CAS number: 96-48-0
Impairment of Growth Concentration 50% (IGC50): 4518 mg/L, Tetrahymena pyriformis
toxicity of γ-butyrolactone (GBL) to microorganisms has been tested
under non-GLP conditions according to methods that examine growth
inhibition of Pseudomonas putida and Tetrahymena pyriformis. In
addition, ready biodegradation and inherent biodegradation tests have
been performed which provide insight into the degree of toxicity to
microorganisms. For studies having a Klimisch score of at least
2, the data are as follows: No toxicity was observed at 1061 mg/L as
part of an OECD 302B inherent biodegradability test (BASF, 1977), a 17
hour EC50 of >10000 mg/L was reported from a Growth Inhibition
(Pseudomonas putida) test (BASF, 1988), and an IGC50 of 4518 mg/L was
reported in a ciliated growth inhibition test with Tetrahmena
pyroformis (Schultz, 1999). Given these results, it can be concluded
that GBL exhibits a low order of toxicity to microorganisms.
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