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EC number: 205-739-4
CAS number: 149-44-0
after oral uptake:
E. performed tests with dogs for sodium formaldehyde sulfoxylate`s
afficacy to be used as an antidote against Mercury poisoning.
tests revealed very slow resorption from the digestive tract after
application by stomach tube such that its bioavailability was too low
for antidote effectiveness.
intravenous injection of sodium formaldehyde sulfoxylate most of it
disappeared from the blood in less than 2 hours and practically all
disappeared within 5 hours.
after dermal exposure:
formaldehyde sulfoxylate is an organic salt which is highly soluble in
the other hand human epidermis is an excellent barrier for salts, in
particular since highly water soluble and charged molecules can not
(easily) penetrate such barrier.
any relevant dermal absorption of this substance is not expected.
formaldehyde sulfoxylate is a solid with a melting point of 64 °C; its
boiling point cannot be determined, because the substance decomposes at
the melting point.
uptake by inhalation may be only relevant after exposure to dusts of the
substance when particles are small enough to pass the tracheal airways
down to the alveoli.
of solid Sodium formaldehyde sulfoxylate in surfactant fluid may then be
expected together with systemic absorption.
substance is highly soluble in water (> 1,000 g/L).
to its strong hydrophilicity, a fast distribution after systemic
absorption into blood, plasma and further water based body fluids is to
be expected as long as biological membranes do not inhibit such
transfer to any lipophilic compartments of the human body is highly
unlikely, the fact of which clearly indicates a very low potency for
parenteral application to dogs the substance disappeared from the blood
in less than 2 hours and practically all disappeared within 5 hours (see
of Sodium formaldehyde sulfoxylate were not identified in the
experiments with dogs (see above), but most of the substance was
excreted renally (up to 68 % within 8 hours after intravenous
simple excretion pattern is plausible, since very hydrophilic substance
do not need metabolic conversion for excretion, i.e. Sodium formaldehyde
sulfoxylate can be directly renally eliminated.
of (unchanged) Sodium formaldehyde sulfoxylate from the body is fast and
obviously does not need any metabolic conversion due to its high water
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