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EC number: 205-739-4 | CAS number: 149-44-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in accordance with the requirements ofthe following directives: - OECD GUIDELINES FOR TESTING OF CHEMICALS, W 405 "Acute Eye Irritation/Corrosion", adopted by the Council on 24th Feb. 1987
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium hydroxymethanesulphinate
- EC Number:
- 205-739-4
- EC Name:
- Sodium hydroxymethanesulphinate
- Cas Number:
- 149-44-0
- Molecular formula:
- CH4O3S.Na
- IUPAC Name:
- sodium hydroxymethanesulphinate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: White New Zealanders
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, D-97320 Sulzfeld
- Age at study initiation:
- Weight at study initiation:
animal no 1: 3714g
animal no 2: 3692g
animal no 3: 3277 g
- Weight at conclusion of the study:
animal no 1: 3754g
animal no 2: 3755g
animal no 3: 3325 g
- Housing: Cages of stainless steel with bottom grid of oval steel and with tub far faeces, dimensions of the cages: 50 x 55 x 40 cm, Bedding: ALTROMIN Type S8115, granulated soft wood bedding
Batches: 120500
- Diet (e.g. ad libitum): ALTROMIN 2123, standard diet for rabbits ad libitum (ALTROMIN, D-32791 LagelLippe), Batch: 05020111049
- Water (e.g. ad libitum): tap water, ad libitum (municipal supply), Makrolon® bottles, changed daily
- Acclimation period: 2 month before administration
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 - 20°C
- Relative Humidity (%): 35 - 50%
- Air changes (per hr): air conditioning
- Photoperiod (hrs dark / hrs light): artificiallight was set to give a cycle of 12 hours light and 12 hours dark; the light phase was from 6.30 a.m. - 6.30 p.m.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: other eye of each animal served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 g of the test item after crushing with a pestle and mortar to a fine dust. - Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- The animals were monitored for general clinical condition continuously on the day of administration and once daily thereafter (in the morning).
The conjunctivae, cornea and iris of the eyes were examined at 1, 24, 48 and 72 hours and on the 4th day after instillation. - Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): the treated eyes were rinsed out with distilled water carefully.
- Time after start of exposure: 24 h
SCORING SYSTEM: see table 1
TOOL USED TO ASSESS SCORE: hand-slit lamp (Heine Optotechnik)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 1,2,3
- Time point:
- other: 1/24/48/72/96 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not affected
- Irritation parameter:
- iris score
- Basis:
- animal: 1,2,3
- Time point:
- other: 1/24/4872/96 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not affected
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 1/24/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 96 h
- Remarks on result:
- other: conjunctivae redness
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 96 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: conjunctivae redness
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 1/24 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: conjunctivae redness
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 48/ 72/96 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: conjunctivae redness
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 1/24 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: conjunctivae redness
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 48/72/96 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: conjunctivae redness
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 96 h
- Remarks on result:
- other: conjunctivae chemosis
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 96 h
- Remarks on result:
- other: conjunctivae chemosis
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 96 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: conjunctivae chemosis
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 1 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: conjunctivae chemosis
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24/48/72/96 hours
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: conjunctivae chemosis
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 1 hour
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: conjunctivae chemosis
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 24/48/72/96 hours
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: conjunctivae chemosis
- Irritant / corrosive response data:
- A slight redness of the conjunctivae of the treated eyes was observed in 2 animals until 24 and in 1 animal until 72 h after instillation. A slight swelling of the conjunctivae was observed in 1 animal until 72 h after instillation. This swelling was shortly increased to a clear swelling 1 h after instillation. In the 2 further animals a slight to clear swelling was observed only 1 h after instillation. The cornea and iris were not affected. 4 d after instillation no signs of irritation were observed.
- Other effects:
- None of the animals died or showed clinical signs during the course of testing.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The alterations of the eyes after instillation of the test item do not meet the criteria for classification of a substance as an eye irritant.
In accordance with the results of this study and in compliance with the criteria of Annex IV of Council Directive 93121/EEC of27th April 1993 the test item has not to be classified as a substance that is irritant to the eye. - Executive summary:
The acute eye irritation/corrosion of the test item was tested in 3 Albino Rabbits. The test item was instilled as the original substance after crushing with a pestle and mortar to a fine dust at a single dose of 0.1 g to one of the eyes in each animal. The untreated eye was used for control.
The animals were examined for clinical signs and the eyes were examined for lesions of the conjunctivae, cornea and iris 1, 24, 48 and 72 h and on the 4th day after instillation of the test item.
The grades for ocular lesions were recorded in accordance with OECD 405.
The instillation of the test item caused a slight redness of the conjunctivae and a slight to short clear swelling of the conjunctivae in 3 three animals.
On the 4thday after instillation no signs of irritations were observed. The cornea and iris were not affected. None of the animals died or showed clinical signs during the course of testing. Signs of systemic effects of the test item were not observed.
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