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Toxicological information

Endpoint summary

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Description of key information

Basic toxicokinetics are derived from secondary literature that does not meet the criteria of today standards. 
Absorption:
oral uptake: Very slow resorption from the digestive tract. Possible in the case of inhaling substance dust.
dermal exposure: Any relevant dermal absorption is not expected.
inhalation: Uptake by inhalation may be relevant after exposure to dusts; due to the particle size distribution only a very limited fraction may pass the tracheal airways down to the alveoli. Most of the substance will be dissolved in water based body fluids, e.g. salivary fluid.
Distribution:
Due to the strong hydrophilicity, a fast distribution after systemic absorption into blood, plasma and further water based body fluids is to be expected. A transfer to any lipophilic compartments of the human body is highly unlikely.
Skin:
No indication of an increase of skin problems caused by exposure (corrosion, irritation, allergic skin sensitization).
Respiratory tract, pulmonary function:
Neither reductions of the pulmonary function appeared nor any indication for an inhalative sensitization due to the inhalation of product dust was given.
CMR, target-organic toxicity
No indication of a development of malignant neoplasia was observed. No indication of specific target-organic toxicity could be determined. This also applies for effects on the respiratory tract and the mucous membranes.
Excretion:
Excretion of (unchanged) substance from the body is fast and obviously does not need any metabolic conversion due to its high water solubility.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Bioaccumulation

The substance shows no bioaccumulation potential. After intravenous injection in dogs most of it disappeared from the blood in less than 2 hours and practically all disappeared within 5 hours.

 

Paths of exposure:

dermal: unlikely (due to ionic structure)

oral: possible (inhaling of dust)

inhalative: unlikely (due to particle size and solubility)

 

Distribution

Fast distribution into blood, plasma and further water based body fluids. Transfer to any lipophilic compartments is highly unlikely.

 

Metabolism

Metabolites were not identified in the experiments with dogs (see above), but most of the substance was excreted renally (up to 68 % within 8 hours after intravenous application). An oxidation of the sulphur containing part of the substance to sulphate may be possible.

 

Excretion

Excretion is fast and obviously does not need any metabolic conversion due to its high water solubility.

 

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