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EC number: 200-300-3
CAS number: 56-93-9
TABLE 1 Summary of Reproductive Tissue Evaluations for Male Rats in the
13-Week Gavage Study of Benzyltrimethylammonium Chloridea
* Significantly different (P<0.05) from the vehicle control
group by Dunnetts test
a Data are presented as mean ± standard error. Differences
from the vehicle control group are not significant by Dunnetts test
weights) or Dunns test (spermatid and epididymal spermatozoal
TABLE 2 Estrous Cycle Characterization for Female Rats in the 13-Week
Gavage Study of Benzyltrimethylammonium Chloridea
a Necropsy body weight and estrous cycle length data are
presented as mean ± standard error. Differences from the vehicle control
group are not significant by Dunnetts test (necropsy body weight) or
Dunns test (estrous cycle length).
b Estrous cycle was longer than 12 days or unclear in one of
c Evidence shows that females administered 25 mg/kg differ
significantly (Wilks Criterion, P<0.05) from the vehicle
control females in the relative length of time spent in the estrous
stages. Dosed females spent more time in proestrus and less time in
diestrus than the
vehicle control females.
13 -week studies, groups of 10 male and 10 female rats received
benzyltrimethylammonium chloride in deionized water by gavage at doses
of 0, 12.5, 25, 50, or 100 mg/kg, 5 days per week for 13 weeks.
Benzyltrimethylammonium chloride generally had little effect on the body
weights of rats. Final mean body weights of dosed animals were within 8%
(rats) of the control group body weights. The deaths of two female rats
administered 100 mg/kg were the result of pharmacologic effects on the
cardiovascular system. Some cholinergic effects including
chromodacryorrhea, lacrimation, salivation, pupillary constriction,
altered gait, and mild tremors were observed at nonlethal doses in rats;
these effects were accompanied by alterations in body position. No
significant target organ toxicity was observed in dosed rats.
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