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EC number: 200-300-3
CAS number: 56-93-9
No additional information available.
This study was conducted to determine the acute inhalation toxicological
properties of benzyltrimethylammonium chloride. Two groups of five
rats/sex were exposed using a nose-only inhalation exposure system, to
time-weighted average chamber concentration of 0.64 or 2.03 mg
benzyltrimethylammonium chloride per liter of air. The mass median aerodynamic
diameter (MMAD) of particulate benzyltrimethylammonium chloride present in
the exposure chamber test atmospheres averaged 2.67 microns with an
average geometric standard deviation (GSD) of 1.89 for the 0.64 mg/L
exposure and 2.28 microns with a GSD of 2.85 for the 2.03 mg/L exposure.
All animals died during exposure to 2.03 mg/L (100% mortality by 97
minutes of exposure. Clinical effects noted prior to death were labored
breathing in 2 male and 2 female rats and soiling of the haircoat in 2
female rats. At necropsy all animals were noted to have liver congestion
All animals survived the four-hour exposure to 0.64 mg/L as well as the
two-week postexposure observation period. There was no in-life
observations noted during the four-hour exposure to 0.64 mg/L.
Observations noted post-exposure were limited to perineal and/or extensive
body soiling in 4 males and 5 females. All rats appeared normal by test
day 2. Mean body weight losses of 1.4 and 2.6% were noted for male and
female rats, respectively, on test day 2. Pre-exposure mean body weight
values were exceeded by test
day 4 and test day 8 for male and female rats, respectively. There were
no visible treatment-related lesions noted in any of the rats exposed to
0.64 mg/L benzyltrimethylammonium chloride at the test day 15-scheduled
Based on these data, the calculated four-hour LC50 of inhaled
particulate benzyltrimethylammonium chloride is 1.14 mg/L for male and
female F344/DuCrl rats.
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