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EC number: 200-300-3
CAS number: 56-93-9
No additional information available.
subchronic toxicity of benzyltrimethylammonium chloride was examined in
F344 rats. In the 13 -week studies, groups of 10 male and 10 female rats
received benzyltrimethylammonium chloride in deionized water by gavage
at doses of 0, 12.5, 25, 50, or 100 mg/kg, 5 days per week for 13 weeks.
Benzyltrimethylammonium chloride generally had little effect on the body
weights of rats. Final mean body weights of dosed animals were within 8%
(rats) of the control group body weights. The deaths of two female rats
administered 100 mg/kg were the result of pharmacologic effects on the
cardiovascular system. Some cholinergic effects including
chromodacryorrhea, lacrimation, salivation, pupillary constriction,
altered gait, and mild tremors were observed at nonlethal doses in rats;
these effects were accompanied by alterations in body position. No
significant target organ toxicity was observed in dosed rats.
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