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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
specific investigations: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results

Data source

Reference
Reference Type:
publication
Title:
Synthesis and Skeletal Muscle Relaxant Activity of Quaternary Ammonium Salts of Dantrolene and Clodanolene
Author:
ELLIS,. K. 0. , WHITE, Jr., R. L, WRIGHT, G. C.and . WESSELS, F. L
Year:
1980
Bibliographic source:
Journal of Pharmaceutical Sciences Vol. 69. No. 3 (March 1980) pp 327-331

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Direct stimulation of the gastrocnemius muscle in rats was examined.
GLP compliance:
no
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyltrimethylammonium chloride
EC Number:
200-300-3
EC Name:
Benzyltrimethylammonium chloride
Cas Number:
56-93-9
Molecular formula:
C10H16N.Cl
IUPAC Name:
benzyltrimethylazanium chloride
Details on test material:
Benzyltrimethylammonium chloride was purchased from Aldrich Chemical Company. No further details provided.

Test animals

Species:
rat
Strain:
other: TAC:SD/NfBr
Sex:
not specified

Administration / exposure

Route of administration:
intravenous
Vehicle:
other: tetrahydrofurfuryl alcohol
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
No data.
Frequency of treatment:
Rats received a single iv treatment
Post exposure period:
No additional information available.
Doses / concentrations
Remarks:
Doses / Concentrations:
25 mg/kg
Basis:
other: iv administered dose
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Details on results:
The maximum percent change in Gastrocnemius Muscle Twitch Response following iv administration of 25 mg/kg benzyltrimethylammonium chloride was 10.1 +/- 1.5.

Any other information on results incl. tables

No additional information available.

Applicant's summary and conclusion

Conclusions:
The maximum percent change in Gastrocnemius Muscle Twitch Response following iv administration of 25 mg/kg benzyltrimethylammonium chloride was 10.1 +/- 1.5.
Executive summary:

The effect of the test material on muscle was evaluated. The maximum percent change in Gastrocnemius Muscle Twitch Response following iv administration of 25 mg/kg benzyltrimethylammonium chloride was 10.1 +/- 1.5.