Registration Dossier
Registration Dossier
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EC number: 200-300-3 | CAS number: 56-93-9
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results
Data source
Reference
- Reference Type:
- publication
- Title:
- Synthesis and Skeletal Muscle Relaxant Activity of Quaternary Ammonium Salts of Dantrolene and Clodanolene
- Author:
- ELLIS,. K. 0. , WHITE, Jr., R. L, WRIGHT, G. C.and . WESSELS, F. L
- Year:
- 1 980
- Bibliographic source:
- Journal of Pharmaceutical Sciences Vol. 69. No. 3 (March 1980) pp 327-331
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Direct stimulation of the gastrocnemius muscle in rats was examined.
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Benzyltrimethylammonium chloride
- EC Number:
- 200-300-3
- EC Name:
- Benzyltrimethylammonium chloride
- Cas Number:
- 56-93-9
- Molecular formula:
- C10H16N.Cl
- IUPAC Name:
- benzyltrimethylazanium chloride
- Details on test material:
- Benzyltrimethylammonium chloride was purchased from Aldrich Chemical Company. No further details provided.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: TAC:SD/NfBr
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- other: tetrahydrofurfuryl alcohol
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- No data.
- Frequency of treatment:
- Rats received a single iv treatment
- Post exposure period:
- No additional information available.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
25 mg/kg
Basis:
other: iv administered dose
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
Results and discussion
- Details on results:
- The maximum percent change in Gastrocnemius Muscle Twitch Response following iv administration of 25 mg/kg benzyltrimethylammonium chloride was 10.1 +/- 1.5.
Any other information on results incl. tables
No additional information available.
Applicant's summary and conclusion
- Conclusions:
- The maximum percent change in Gastrocnemius Muscle Twitch Response following iv administration of 25 mg/kg benzyltrimethylammonium chloride was 10.1 +/- 1.5.
- Executive summary:
The effect of the test material on muscle was evaluated. The maximum percent change in Gastrocnemius Muscle Twitch Response following iv administration of 25 mg/kg benzyltrimethylammonium chloride was 10.1 +/- 1.5.
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