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EC number: 200-300-3
CAS number: 56-93-9
Initially, a group of three males and three females was dosed at 200
mg/kg body weight. Additional groups of 3 males and 3 females were
selected in chronological order 2000, 650 and 400 mg/kg body weight.
Table 1 Mortality
Assessment of acute dermal toxicity with BTMAC-60% in the rabbit was
carried out based on the guidelines described in: EC Commission
Directive 92/69/EEC, Part B.3, "Acute Toxicity Dermal" and OECD # 402,
"Acute Dermal Toxicity".
BTMAC-60% was administered to three rabbits of each sex by dermal
application at 200, 400, 650 or 2000 mg/kg body weight for 24 hours.
Animals were subjected to daily observations and weekly determinations
of body weight. Macroscopic examination was performed on the day of
death or after terminal sacrifice (day 15).
The incidence of mortality from low to high dose level was 0/3, 0/3,
2/3, 3/3 for males and 0/3, 1/3, 3/3, 3/3 for females. the decedents
were found dead on days 1 and 2. One male and two females dosed at 2000
mg/kg were killed in extremis on day 1.
Lethargy, flat posture, quick and slow breathing, (excessive)
salivation, pale skin and diarrhea was noted among the animals that
died. Lethargy was noted in the surviving animals of the 650 and 400
mg/kg dose group on day 1 only. No clinical signs were noted in the
animals dosed at 200 mg/kg.
Scales were seen in the treated skin-area among the animals treated at
400 mg/kg between days 5 and 8.
The changes noted in body weight pain in surviving males and females
were considered to be normal.
Macroscopic post mortem examination of the animals that died or were
killed in extremis during the study revealed hemorrhages or dark red
foci in the thymus, thickening of the fundus in the stomach, irregular
surface of the lungs and hemorrhagic fluid in the abdominal cavity. Dark
red discoloration of hte subcutis of the treated skin area was found in
two females dosed at 2000 mg/kg. Macroscopic post mortem examination of
the surviving animals at termination did not reveal any abnormalities.
The dermal LD50 values of BTMAC-60% in rabbits were calculated to be 633
mg/kg body weight for the males, 410 mg/kg body weight for the females
and 510 mg/kg body weight for the sexes combined. Due to the mortality
distribution, no fiducial limits could be determined for the LD50 values
for males and females.
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