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EC number: 205-597-3 | CAS number: 143-28-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an appropriate national standard method but full details are not available.
Data source
Reference
- Reference Type:
- publication
- Title:
- Safety evaluation of cosmetic raw materials.
- Author:
- Guillot J P et al
- Year:
- 1 977
- Bibliographic source:
- J. Cos. Chem. 28:377-393
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test method used was a modification of the French offical method for testing cosmetics and Toiletries, 1971 & 1973. Each sample was tested undiluted and as a 10% aqueous dispersion using an emulsifier and preservative. Four samples of Oleyl alcohol from different manufacturers were tested. The composition of the samples was determined by GLC. Of the 4 samples tested one was less pure than the others.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (Z)-octadec-9-enol
- EC Number:
- 205-597-3
- EC Name:
- (Z)-octadec-9-enol
- Cas Number:
- 143-28-2
- Molecular formula:
- C18H36O
- IUPAC Name:
- (9Z)-octadec-9-en-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Cas# 143-28-3 Oleyl alcohol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: in individual cages (600x540x315 mm)
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: applied undiluted as a 10% aqueous dispersion
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Concentration (if solution): Each sample was tested undiluted and as a 10% aqueous dispersion using an emulsifier and preservative. (Product 10 -15%, polyoxyethylene sorbitan stearate 3%, Preservative 0.2%, Water 100%)
- Duration of treatment / exposure:
- A single instillation.
- Observation period:
- 1h, 24h, 48h
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Type of wrap if used: Occlusive patches were used which were fixed using absorbent gauze held in place by adhesive tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not washed
SCORING SYSTEM: Non irritant; less than 0.5, slightly irritant 0.5 to 2.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 1.71
- Remarks on result:
- other: Undiluted
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 1.58
- Remarks on result:
- other: Undiluted
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 0.17
- Remarks on result:
- other: 10% aqueous dilution
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 0.33
- Remarks on result:
- other: 10% aqueous dilution
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 1.67
- Remarks on result:
- other: Undiluted
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 1.75
- Remarks on result:
- other: Undiluted
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 0.04
- Remarks on result:
- other: 10% aqueous dilution
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 0.25
- Remarks on result:
- other: 10% aqueous dilution
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 1.5
- Remarks on result:
- other: Undiluted
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 0.29
- Remarks on result:
- other: 10% aqueous dilution
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 1.33
- Remarks on result:
- other: Undiluted
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 0.42
- Remarks on result:
- other: 10% aqueous dilution
- Irritant / corrosive response data:
- The maximum index of 1.75 was found with Oleyl alcohol when tested undiluted. The average score of 0.28 was calculated for the diluted test substance.
- Other effects:
- When applied undiluted, exposure to the test substance resulted in important thickening and drying of the skins, eschars and fissures. When applied as a 10% solution the test substance was relatively well tolerated, with slight epidermal exfoliation.
Any other information on results incl. tables
The undiluted samples produced thickening and drying and cracking of the skin with eschars. Histological examination typically revealed
hyperacanthosis and a flattened stratum corneum.
The 10% aqeuous dilutions were relatively well tolerated. Slight epidermal exfoliation was observed with 3 samples. Histological
examination showed showed some vascular congestion of the dermis without inflammatory infiltration.
None of the test samples revealed evidence of hypersensitivity on challenge.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Journal Officiel de la republique Francaise.
- Conclusions:
- The test substance was found to be slightly irritating, but not requiring classification, in a reliable study conducted according to generally accepted scientific principles.
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