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EC number: 205-597-3
CAS number: 143-28-2
Inhibition of WWTP microorganisms ((Z)-octadec-9-enol): no significant inhibitory effects on respiration of activated sludges or specific microbial strains relevant to WWTP, at or above the limit of solubility (based on inhibition tests and lack of toxicity in ready biodegradability tests).
accordance with Column 2 of REACH Annex VIII, the activated sludge
respiration inhibition study (required in Section 9.1.4 of REACH) does
not need to be conducted as the substance is readily biodegradable and
the applied test concentrations are in the range that can be expected in
the influent to a sewage treatment plant. One reliability 2 study is
available, for the species Pseudomonas putida. An EC0
of 10000 mg/l was determined, i.e. the EC50 is greater than
the limit of solubility.
supported by results of non-assignable reliability studies with shorter
chain-length alcohols indicating EC50 in the hundreds of mg/l
for respiration of a mixed microbial culture.
of trends in the Category of C6-24 linear and essentially-linear
A number of
studies of the toxicity of LCAAs to single species of micro-organisms
have been identified. A range of results are shown in Table 7.21 of the
Category CSR, for test species relevant to WWTP (studies on various
other organisms are also available).
biodegradation studies (Federle, 2009 and Flach, 2012, discussed in
Section 5.2.1) gives evidence that rapid biodegradation by aquatic
activated sludge microorganisms is seen, even in the presence of an
excess of test substance (for the longer chain length category members
tested). It is notable that the biodegradation in the ready test was
very high compared to ThCO2, indicating that over the course
of the test the exposure of organisms to test substance must have been
At or above
the limit of solubility, the data set shows that the alcohols in the
chain length range C6-24 category have no significant inhibitory effects
on respiration of activated sludges or specific microbial strains
relevant to WWTP. There is limited evidence of inhibition of growth in
some specific microbial strains but ready biodegradation evidence
suggests this is not significant for mixed populations.
reliability of some of these data individually is not high, but it
presents a consistent weight of evidence.
it can be said that the micro-organisms examined in these tests were
less susceptible to the LCAAs than fish, invertebrates and algae and
that in general, IC50values for respiration effects are at or
significantly above the limit of water solubility.
microorganisms have been demonstrated to be capable of synthesising
significant concentrations of aliphatic alcohols (e.g. Mudge et al.,
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