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EC number: 205-597-3
CAS number: 143-28-2
The key result for acute toxicity was read across from hexadecan-1-ol (CAS 36653-82-4), reporting an LD50 value of >2000 mg/kg (Hempstock 1996; rel 1). This is supported by data on the substance Alcohols, C16-18 and C18-unsat., which contained between 40 and 90% of unsaturated octadecan-1-ol, which indicates that the LD50 was >5000 mg/kg bw (Henkel KGaA. 1981h) . The acute dermal toxicity was read across from 1-tetradecanol (CAS 112-72-1), reporting an LD50 value of 8000mg/kg (Scientific Associates 1977; rel 2). Data for the inhalation toxicity endpoint were not available, but further testing was not scientifically justifiable since sufficient information via the oral and dermal endpoints was available. Further more, weight of evidence across category suggests the LC50 to be expected to be greater than the substantially saturated vapour concentration..
The LC50 for inhalation toxicity is expected to be greater
than the substantially saturated vapour concentration, based on weight
of evidence across category of other linear alcohols. The available
information includes data on C12 -16, C14 (tetradecan-1-ol), C16
(hexadecan-1-ol), C16 -18, C18 (octadecan-1-ol), and C20 (eicosan-1-ol).
The key study for acute oral toxicity is read across from hexadecan-1-ol
which has been tested for acute oral toxicity in a study conducted
according to OECD 401 and in compliance with GLP (Hempstock 1996; rel
1). No deaths occured and no evidence of toxicity was observed when 10
male and 10 female rats were dosed with 2000 mg/kg bw of hexadecan-1-ol
by oral gavage. It was concluded that the rat oral LD50 was >2000 mg/kg
The key acute oral study is supported by data on the substance Alcohols,
C16-18 and C18-unsat., which contained between 40 and 90% of unsaturated
octadecan-1-ol. Only a summary was available for review. Five animals
per sex were dose by gavage with 5000 mg/kg bw in a study conducted
according to OECD 401 and in compliance with GLP; only a summary was
available for review. No deaths occurred and therefore the LD50 was
determined to be >5000 mg/kg bw (Henkel KGaA. 1981h).
The key acute dermal study is read across from tetradecan-1-ol (CAS
112-72-1). The study predates the OECD guideline was conducted according
to a protocol similar to the guideline. No deaths were reported when two
male and two female rats were exposed occlusively to 2, 4 and 8 g/kg bw
for 24 hours. The test substance was applied to abraded skin in one
animal of each sex . The animals were observed for 14 days after
exposure. One male and one female rabbit died in the high dose group
only, so it was concluded that the LD50 was 8000 mg/kg bw (Scientific
Associates 1977; rel 2). Both deaths occurred in animals where the test
substance had been applied to abraded skin.
Discussion of trends in the Category of C6-24 linear and
essentially-linear aliphatic alcohols:
Acute toxicity tests of the linear and essentially linear alcohols do
not indicate any potential hazard for acute, dermal or inhalation
toxicity. Tests on various substances included in this category are all
supportive of these results and do not warrant classification for most
of the acute toxicity endpoints under GHS criteria. The majority of the
substances are therefore not classified for acute toxicity in accordance
with EC regulation 1272/2008. The only exception to this is hexan-1-ol,
which finds that the acute dermal data for the test substance are
consistent with Acute dermal tox category 4 and Acute oral tox 4
H302/R22, in line with the Annex VI entry.
Based on the above information, there is no requirement for
classification or labelling of (Z)-octadec-9-enol for any of the acute
toxicity endpoints, in accordance with CLP Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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