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EC number: 205-597-3
CAS number: 143-28-2
No reliable, standard tests of soil microbial inhibition are available. The terrestrial chemical safety assessment has been conducted using the Equilibrium Partitioning method (EQPM).
The terrestrial chemical safety assessment
has been conducted using the Equilibrium Partitioning method (EQPM). It
is recognised that the aquatic PNEC used in the EQPM does not take into
account any indicator for effects in aquatic microorganisms. However,
testing analogous alcohols within the Category shows the substances in the
category are very rapidly biodegradable and show no significant
inhibitory effects on respiration of activated sludge or specific
microbial strains relevant to WWTP, at or above the limit of solubility
(based on inhibition tests and lack of toxicity in ready
biodegradability test). Therefore it is unlikely that the PNECterrestrial
based on aquatic ecotoxicity test results would not be protective for
terrestrial microorganisms. The chemical safety assessment using EQPM
does not suggest any unacceptable risks for the terrestrial compartment.
Therefore, further toxicity testing with
terrestrial microorganisms does not need to be conducted.
Moreover, considerable technical
difficulties would be expected in the conduct of such a test, due to the
very rapid biotic removal of the substance from the test system. Please
refer to discussion of the long-term aquatic invertebrate and fish
studies (Section 6.1.2 and 6.1.4), and evidence of rapid removal in
non-sterilised soils during method development for the
adsorption/desorption study with natural soils (Section 5.4.1 and 5.2.3).
A lack of toxicity to soil microbiota was
suggested by a recent experimental finding associated with a recent
study of adsorption/desorption (OECD 106, Wildlife International, 2015)
using decan-1-ol. Significant technical difficulties were encountered
during method development for this study using natural standard soils,
in that it was not possible to detect sufficient substance and establish
equilibrium in non-sterilised soil samples. During method development in
preparation for this study, the laboratory reported that after
equilibration with soils for 15-minute to 24-hour periods, decan-1-ol
dosed into the test vessels was partly or completely transformed into a
more polar product, which was clearly distinguishable from the starting
material as clear and well separated peaks in the chromatograms. The
rate of transformation depends on the soil type. Only after a very short
(5-minute) equilibration the parent material remained intact (personal
communication, 8 January 2015 from Wildlife International laboratory).
Half-lives were not explicitly derived, but chromatograms presented
would indicate the half-life of decan-1-ol in the soil test samples was
approximately 30 min - 1 hour (silt loam soil); 1 - 2 hours (loamy
sand), and 15 - 30 minutes (clay loam). Following sterilisation of the
soil samples by autoclaving, the substance remained adequately stable
for a 2-hour period, therefore the instability can be attributed to
biodegradation of the substance by soil microbiota. The polar
degradation product is most likely the corresponding carboxylic acid,
though it was not definitively identified. The chromatograms show that
decan-1-ol was effectively fully removed in all four soil types by the
24 h time point (in the case of 2 of the soil types, within 2 hours),
suggesting the microbial population was not inhibited by decan-1-ol,
though this is evidence is not in itself adequate as key data.
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