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EC number: 205-517-7
CAS number: 141-98-0
Developmental toxicity test was done according to OECD Guideline 414. Wistar pregnant female rats were exposed to test item concentration of 3, 10 and 30mg/kg bw/day for 20 days. There were no test item related findings in maternal animals. There were increased incidences of rudimentary cervical rib (7th) and misshapen humerus in high dose (HD) group compared to the corresponding control and were considered to be adverse effects. In addition, in the same group, increased incidences of reversible skeletal variations and reduced fetal weights were considered signs of test item related embryotoxicity. Thus, the NOAEL for the maternal toxicity is 30 mg/ kg body weight/ day and the NOAEL for the embryo-fetal developmental toxicity is 10 mg/ kg body weight/ day.
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