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EC number: 205-517-7
CAS number: 141-98-0
Stimulation indices (SI)*:
Group 1, negative control
Group 3, 10%
Group 4, 25%
Lymph node cell count
Lymph node weight
____ significantly different from control at p ≤ 0.01
*Values above 1.4 (lymph node cell count to identify sensitisation) or 1.1 (ear weight to identify irritation) are considered positive (these values were fixed empirically during the inter-laboratory validation of this method (Ehling et al. 2005a and Ehling et al. 2005b)
An in vivo skin sensitization LLNA test in female mice with the test substance at concentrations of 5%, 10% or 25% (w/w) in acetone/olive oil (3+1, v/v) was performed equivalent and similarly with OECD Guideline 429. In the current study, instead of a radioactive method an alternative method was used, employing the lymph node weight and lymph node cell count to assess proliferation. Stimulation indices were consequently calculated for the lymph node cell count, lymph node weight, ear weight and ear thickness by dividing the average values per group of the test item treated animals by the vehicle treated ones. Based on the obtained test results and in accordance with the criteria of Classification, Labelling and Packaging of Substances and Mixtures Regulation (EC) No 1272/2008 (CLP Regulation), the test substance is not classified as skin sensitizer.
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