Registration Dossier

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7860 (Water Solubility Generator Column Method)
GLP compliance:
no
Type of method:
flask method
Key result
Water solubility:
ca. 2.96 g/L
Temp.:
25 °C
pH:
ca. 4
Key result
Water solubility:
ca. 2.65 g/L
Temp.:
25 °C
pH:
ca. 7
Key result
Water solubility:
ca. 2.59 g/L
Temp.:
25 °C
pH:
ca. 9

Preliminary test

After the addition of 100 mL of buffer the test item was completely dissolved. Hence the preliminary test displayed solubility of the test item between 1 and 10 g/L. This is the case for all three buffer solutions.

When the test item is added aqueous solution, excess material is found at the surface of the aqueous solution. This makes it difficult to execute the flask method according to the guidelines, since the risk of contamination when taking an aliquot of the aqueous solution for analysis is too high. However, since the solubility is relatively high (1 to 10 g/L), the water solubility is determined using an extended preliminary test. This was done for all threee buffer solutions.

Conclusions:
Interpretation of results: soluble (1000-10000 mg/L)
The water solubility at 25ºC and pH 4: 2.96 g/L, pH 7: 2.65 g/L, pH 9: 2.59 g/L

Description of key information

The water solubility at 25ºC and pH 4: 2.96 g/L, pH 7: 2.65 g/L, pH 9: 2.59 g/L

Key value for chemical safety assessment

Water solubility:
2.65 g/L
at the temperature of:
25 °C

Additional information

Categories Display