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EC number: 205-517-7
CAS number: 141-98-0
A repeated dose 90 day oral toxicity study was performed in rats, orally administered with 30, 100, 300 mg/kg bw/day of the test substance in corn oil according to OECD Guideline 408. Based on histomorphological findings a NOAEL value of 300 mg/kg bw/day was determined in female rats, whereas in male rats, the NOAEL obtained was 100 mg/kg bw/day based on the presence of centrilobular hepatocellular vacuolation. In support of histopathological findings indicating liver toxicity at the high dose, moderate changes in liver markers of clinical chemistry and increased liver weights were observed. Both effects were shown in males and females in similar extent. A moderate body weight loss was recorded for male animals. Considering the range of affected liver parameters the overall NOAEL of IPETC for systemic toxicity in the current study study is considered to be at 100 mg/kg bw/day.
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