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Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
January 2013 - March 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
O-isopropyl ethylthiocarbamate
EC Number:
205-517-7
EC Name:
O-isopropyl ethylthiocarbamate
Cas Number:
141-98-0
Molecular formula:
C6H13NOS
IUPAC Name:
O-isopropyl ethylthiocarbamate
Test material form:
gas under pressure: liquefied gas
Radiolabelling:
no

Study design

Analytical monitoring:
yes
Buffers:
Buffer pH 4,
Buffer pH 7,
Buffer pH 9,
Duration of testopen allclose all
Duration:
168 h
pH:
4
Initial conc. measured:
> 0.09 - < 0.107 g/L
Duration:
120 h
pH:
7
Initial conc. measured:
> 0.1 - < 0.1 g/L
Duration:
120 h
pH:
9
Initial conc. measured:
> 0.096 - < 0.096 g/L
Number of replicates:
2 replicates pr pH value
Positive controls:
not specified
Negative controls:
not specified

Results and discussion

Transformation products:
not specified
Total recovery of test substance (in %)open allclose all
% Recovery:
> 99.5
pH:
4
Temp.:
50 °C
Duration:
168 h
% Recovery:
> 99.7 - < 103
pH:
7
Temp.:
50 °C
Duration:
120 h
% Recovery:
> 108 - < 115
pH:
9
Temp.:
50 °C
Duration:
120 h
Dissipation DT50 of parent compoundopen allclose all
Key result
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
other: Estimated from results at 50 ºC
Key result
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
other: Estimated from results at 50 ºC
Key result
pH:
9
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
other: Estimated from results at 50 ºC

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The test item was found not to hydrolyse at pH 4 - 7 - 9, half-life greater than 1 year at 25 ºC

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