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EC number: 604-195-9
CAS number: 1406-66-2
differences in reproductive indices were seen between controls and
treated groups of parents. Mean gestation period, litter size, sex
ratio, and mortality of pups and parents were unaffected by the test
clinical chemistry done after 255 days of treatment revealed no
toxicologic differences between control and high dose group. None of the
organ weights (neither absolute nor relative) of the treated groups were
significantly different from control. Microscopic examination of tissues
of high dose and control F0 and F1b animals revealed no morphological
changes that were attributable to ingestion of the test substance.
Ingestion of the
test substance had no effect on body weight gain of the pups.
Based on default values in the REACH
guidance Chapter R.8: Characterisation of dose [concentration]-response
for human health (Table R8 -17); using the daily intake of 20 gram/day:
and the average body weight of the rats of 0.5 kg (data of the 90 day
study), the NOAEL of 2% is converted to 800 mg/kg bw/day.
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