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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

The aquatic toxicity of the mixed-Tocopherols (CAS: 1406-66-2) is evaluated on the basis of read across data to DL-alpha-Tocopherol (CAS: 10191-41-0) and/or of the precursor of alpha-Tocopheryl acetate (CAS: 7695-91-2).

acute toxicity in fish:

The acute toxicity in fish was evaluated on the basis of a read across data to the structural isomer DL-alpha-tocopherol (CAS: 10191-41-0): The test was performed according to OECD 203 in rainbow trout (Oncorhynchus mykiss(reported asSalmo gairdneri))under GLP. After 96 h exposure a LC0/LC50 were determined to be > 10 mg/L.

  

acute toxicity in daphnia:

The acute toxicity in daphnia was evaluated on the basis of a read across data to the structural isomer DL-alpha-tocopherol (CAS: 10191-41-0) and /or the precursor DL-alpha-tocopheryl acetate (CAS: 7695-91-2):

 

One test was performed with DL-alpha-tocopherol (CAS: 10191-41-0) according to OECD 202 in waterflea (Daphnia magna) under GLP. After 48 h exposure the EC 50 was determined to be > 23 mg/L .

 

A further test was performed for DL-alpha-tocopheryl acetate (CAS: 7695-91-2) according to DIN 38412/11 without GLP, in waterflea (Daphnia magna). In the study the EC 50 after 48 h exposure was determined to be > 500 mg/L .

 

 

 acute toxicity in algae:

The acute toxicity in algae was evaluated on the basis of a read acorss data to the structural isomer DL-alpha-tocopherol (CAS: 10191-41-0) and/or the precursor DL-alpha-tocopheryl acetate (CAS: 7695-91-2):

 

One test was performed with DL-alpha-tocopherol (CAS: 10191-41-0) according to OECD 201 and GLP. After 72 h exposure the EC 50 and NOEC were determined to beto be > 25.8 mg/L and 25.8 mg/L, respectively,related to growth rate.

 

A second test was performed for DL-alpha-tocopheryl acetate (CAS: 7695-91-2) according to OECD 201 and GLP. After 72 h exposure the EC 50 and NOEC were determinedto be > 27.8 mg/L and 27.8 mg/L, respectively,related to growth rate.

 

acute toxicity against mircoorganisms:

Two bacteria tests for read across are available for the group of tocopherols and tocopheryl acetates:

One test was performed with DL-Alpha-Tocopheryl acetate, a precursor of the substance. The respiration rate of microorganisms in presence of DL-Alpha-Tocopheryl acetate was tested by a oxygen consumption test according to ROBRA focusing on the respiration of Pseudomonas putida. After 30 minutes an EC10 > 10000 mg/l was determined (BASF AG, 1991).

In another test changes in the respiration rate of activated sludge as induced by DL-Alpha-Tocopheryl acetate were studied in a test performed in compliance with ISO 8192. An EC20 > 927 mg/l was determined after an inoculation time of 30 minutes.

The study with Pseudomonas putida (BASF AG, 1991) is selected as key study.