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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

The 48h-EC50 of DL-apha-Tocopherol a closely related stereo isomer and/or structure isomer of the mixed Tocopherols towards Daphnia magna was 23.5 mg/l (measured).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
23.5 mg/L

Additional information

Data from a stereo isomer - D, L, alpha Tocopherol - are available for read read across to evaluate the toxicity of alpha-Tocopherol against daphnia. The toxicity of D,L-alpha-TocopheroltowardsDaphnia magnawas investigated according to OECD Guideline 202 under GLP conditions (Maetzler, 2000). The measured 48h-EC50 was >23.5 mg/l.

An acute toxicity study is also for DL-alpha-tocopheryl acetate to D. magna available: Toxicity was investigated in a static test system following German standard DIN 38412, part L11. The 48h EC0 was 500 mg/l and the 48h EC50 was >500 mg/l (BASF AG, 1988). The study was considered to be a supporting study.