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EC number: 604-195-9
CAS number: 1406-66-2
The acute dermal toxicity of the test item was investigated in five
female and 5 male New Zealand White rabbits.
Prior to administration abrasion of the skin was performed on the
exposure sites of 3 males and 2 females. The skin of the remaining 2
male and 3 female rabbits was left intact. Abrasions were made with the
point of a 22 gauge disposable hypodermic needle. The abrasions were
minor incisions through the stratum corneum that were not sufficiently
deep to disturb the derma or to produce bleeding.
One animal was found dead on day 14. Some animals showed decreased
acitivity, loss of appetite, nasal discharge and diarrhea. Three animals
showed weight loss.
The acute dermal median lethal dose (LD50) of the test item in the
rabbit was estimated to be greater than 5000 mg/kg body weight.
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