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EC number: 604-195-9
CAS number: 1406-66-2
No changes in bodyweight gain were seen. No mortality occurred. No skin
reactions were noted after challenge.
The test substance was tested for its sensitization potential in guinea
pigs, using the method of B. Magnusson and A. M. Kligman, J. Invest.
Dermatol. 52, 268 -276 (1969). First the minimum irritant concentration
for the induction application (intracutaneous and epidermal) and the
maximum non irritant concentration for the challenge application were
estimated in separate tests. For the main test 20 female test animale
and 20 controls, Pirbright white strain, were used. The initial average
body weight of the test group animals was 333.8 g, that one of the
control animals was 314.0 g. The test substance was applied in oily
dilutions. 24 and 48 hours after removing of the patches of the
challenge application no skin reactions were observed on the test
animals as well as on the control animals. According to these test
results the test substance can be regarded as a "non sensitizer' for
albino guinea pigs.
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