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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Non-GLP study that meets key elements of current OECD 402 guideline with some notable restrictions (8 day observation instead of 14, skin surface area <10%). Suitable for use in classification if dermal absorption rate and oral toxicity taken into account.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
8-day observation period instead of 14; skin surface area <10%, top dose was only 200 mg/kg
Principles of method if other than guideline:
Method: other: BASF-Test
GLP compliance:
no
Test type:
other: Acute dermal toxicity

Test material

Constituent 1
Chemical structure
Reference substance name:
But-2-ene-1,4-diol
EC Number:
203-787-0
EC Name:
But-2-ene-1,4-diol
Cas Number:
110-64-5
Molecular formula:
C4H8O2
IUPAC Name:
2-Butene-1,4-diol
Constituent 2
Chemical structure
Reference substance name:
(Z)-2-butene-1,4-diol
EC Number:
228-085-1
EC Name:
(Z)-2-butene-1,4-diol
Cas Number:
6117-80-2
Molecular formula:
C4H8O2
IUPAC Name:
but-2-ene-1,4-diol
Details on test material:
- Name of test material (as cited in study report): Buten-2-diol-1,4 (cis)

Test animals

Species:
rabbit
Strain:
Vienna White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: 50 cm²

REMOVAL OF TEST SUBSTANCE
- Washing : After the exposure time the skin was washed with detergent and water

Duration of exposure:
24 hours
Doses:
200 mg/kg bw
No. of animals per sex per dose:
5 males, 5 females
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 200 mg/kg bw
Based on:
test mat.
Mortality:
No mortality was observed.
Clinical signs:
other: No abnormal clinical signs were observed.
Gross pathology:
No abnormalities were noted at necropsy.

Any other information on results incl. tables

 Dose  Sex  1 h  24 h  48 h  8 days
 200 mg/kg  male  0/5  0/5  0/5  0/5
 200 mg/kg  female  0/5  0/5  0/5  0/5

Applicant's summary and conclusion