Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: basic data given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1959
Report Date:
1959

Materials and methods

Principles of method if other than guideline:
Method: other: BASF-Test
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Buten2-diol-1,4

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 10 %
Doses:
1600, 800, 640, 400, 200 µl/kg
No. of animals per sex per dose:
1600 and 200 µl/kg: 3 animals; 800, 640 µl/kg: 10 animals; 400 µl/kg:5 animals
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 856 mg/kg bw
Based on:
test mat.
Mortality:
1600 µl/kg: animal died within 24 hours; 800 µl/kg: 6 animals died after 24 hours; 640 µl/kg: 2 animals died after 24 hours, 1 animal died after 48 hours
Clinical signs:
Depression, stagger, respiration disorder
Gross pathology:
NAD

Any other information on results incl. tables

Originally: LD50 ca. 0.8 ml/kg

 Dose µl/kg  number of dead animals  1 hour  24 hours  48 hours  7 days
 1600  3/3  0/3  3/3    
 800  6/10  0/10  6/10  6/10  6/10
 640  3/10  0/10  2/10  3/10  3/10
 400  0/5        0/5
 200  0/3        0/3
 control animal          0/20

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU