Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) with restrictions (partly limited documentation; nominal atmosphere concentration; vapour only). Not suitable for classification if aerosol exposure likely.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1959
Report Date:
1959

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Version / remarks:
Inhalation hazard test (Annex)
Deviations:
yes
Remarks:
nominal air concentration, vapour only
Principles of method if other than guideline:
Method: other: BASF-Test (Inhalation Risk Test)
GLP compliance:
no
Test type:
other: Inhalation Risk Test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: conditioned air
Details on inhalation exposure:
Rats exposed for 2 h and 8 h, respectively, to a vapour saturated atmosphere.

Vapour was generated by bubbling 200 l/h dry air (no CO2) through the liquid substance column (volume ca. 50 ml) of about 5 cm above a fritted glass disc in a glass cylinder. The glass cylinder was heated in a water bath. The air pressure was 730 - 740 mm Hg . Temperature in the exposure chamber was 20°C.

The saturated vapour pressure was calculated to be approximately 0.024 mg/L at 20°C.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
0.024 mg/l (nominal), saturated vapour concentration at 20°C.
No. of animals per sex per dose:
3
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
0.024 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: Inhalation Hazard test
Mortality:
No mortality was observed.
Gross pathology:
No abnormal findings.

Applicant's summary and conclusion