Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Accepted method of estimation for risk assessment

Data source

Reference
Reference Type:
other: Estimate
Title:
Unnamed
Year:
2010

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Estimated using U.S. EPA DERMWIN v1.43a (September 2008)
Principles of method if other than guideline:
The Dermal Permeability Coefficient Program (DERMWIN) estimates the dermal permeability coefficient (Kp) and the dermally absorbed dose per event (DAevent) of organic compounds.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
SMILES : OCC=CCO
CHEM : 2-Butene-1,4-diol
MOL FOR: C4 H8 O2
MOL WT : 88.11
Log Kow: -0.9 (user entered)
Radiolabelling:
no

Test animals

Species:
other: Estimate
Strain:
other: Estimate

Administration / exposure

Details on study design:
Log Kow (user-entered): -0.9 (used in Kp calculations)

GENERAL Equation: log Kp = -2.72 + 0.71 log Kow - 0.0061 MW

ALCOHOL Class Equation: log Kp = 0.544 log Kow - 2.884

Results and discussion

Any other information on results incl. tables

GENERAL Equation:  Kp (predicted): 1.27e-004 cm/hr

Alchol Class Equation: Kp (predicted): 4.2e-004 cm/hr

Dermally Absorbed Dose per Event:

  Water Conc (mg/cm3): 7.4e+002 (estimated by program)

  Event Duration (hr): 1

  DA(event): 0.094 mg/cm2-event (using Fick's first law)

  DA(event): 0.15 mg/cm2-event (using eqn 5.20 & 5.21)

                  (tau = 0.3 hr, t* = 0.72 hr)

 

Applicant's summary and conclusion