Registration Dossier
Registration Dossier
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EC number: 500-057-6 | CAS number: 27104-30-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (GLP)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 402, EC B.3, OPPTS 870.1200
- Deviations:
- no
- Remarks:
- 24 hours exposure
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Tetrakis(hydroxymethyl)phosphonium chloride, oligomeric reaction products with urea
- EC Number:
- 500-057-6
- EC Name:
- Tetrakis(hydroxymethyl)phosphonium chloride, oligomeric reaction products with urea
- Cas Number:
- 27104-30-9
- Molecular formula:
- C5H16ClN2O5P
- IUPAC Name:
- Phosphonium, tetrakis(hydroxymethyl)-, chloride (1:1), polymer with urea
- Details on test material:
- technical product
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 2000 mg/kg bw
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 14 days
- Number of animals:
- 5m, 5fm
Results and discussion
In vivo
Results
- Irritation parameter:
- other: scar formation
- Basis:
- animal #3
- Time point:
- other: day 9 post exposure
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not reversible
- Remarks on result:
- other: female rats
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- 2000 mg/kg bw of Aflammit SAP is corrosive to skin after 24 hours exposure. Scar formation becomes visible at day 9 post application.
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