Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
other: publications
Adequacy of study:
key study
Study period:
not reported
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The publications about Hydrolysis of THPX species refer to good quality studies.
Cross-reference
Reason / purpose:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Unnamed
Year:
2000
Reference Type:
publication
Title:
Unnamed
Year:
1963
Reference Type:
publication
Title:
Unnamed
Year:
2009

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The publications refer to hydrolysis studies at different pHs (5, 7, 11) with analytics.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
not specified

Study design

Analytical monitoring:
not specified
Positive controls:
not specified
Negative controls:
not specified

Results and discussion

Preliminary study:
It could be shown with 31P-NMR analytic during a Zahn-Wellens-Test that after 24 days the parent compound THPC-urea oligomer has completely disappeared. As major metabolites trihydroxymethyl phosphine oxide (THPO) and bishydroxymethyl phosphonic acid (BMPA) were both found analytically.
Transformation products:
yes
Identity of transformation productsopen allclose all
No.:
#1
Reference
Reference substance name:
Unnamed
IUPAC name:
THPO, Tris-(hydroxymethyl)-phosphinoxide
No.:
#2
Reference
Reference substance name:
Unnamed
IUPAC name:
BMPA, Bishydroxymethyl phosphonic acid
Details on hydrolysis and appearance of transformation product(s):
Hydrolysis of THPC-urea is highly pH-dependent, as it is for THPC and THPS also. The fastest degradation occurs at pH 11. Major metabolites were trihydroxymethyl phosphine oxide (THPO) and bishydroxymethyl phosphonic acid (BMPA), which were both found.
Other kinetic parameters:
Degradation of THPS follows the first-order kinetics.
Details on results:
Hydrolysis of THPC-urea is highly pH-dependent, as it is for THPC and THPS also. The fastest degradation occurs at pH 11. Major metabolites were trihydroxymethyl phosphine oxide (THPO) and bishydroxymethyl phosphonic acid (BMPA), which were both found.

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
Hydrolysis of THPC-urea is highly pH-dependent, as it is for THPC and THPS also. The fastest degradation occurs at pH 11. Major metabolites were trihydroxymethyl phosphine oxide (THPO) and bishydroxymethyl phosphonic acid (BMPA), which were both found in the water.