Registration Dossier
Registration Dossier
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EC number: 500-057-6 | CAS number: 27104-30-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The read across substance THPS was investigated in terms of acute toxicity (96 h): The results are as follows:
Bluegrill sunfish (freshwater): LC50 = 93 mg/L, NOEC = 22.7 mg/L
Sheepshed minnow (marine): LC50 = 72 mg/L, NOEC = 41 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 93 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 72 mg/L
Additional information
The technical product "Tetrakis(hydroxymethyl)phosphonium chloride, oligomeric reaction products with urea" (THPC-urea) is a condensate of THPC and urea. The functional group of the THPC is the OH group. The functional group of the urea is the amino group NH2. The condensation of THPC and urea does not change both functional groups.
The first read across approach between THPC and THPS is considered applicable, as the organic phosphonium cation, which is the responsible part for the toxicological effects, is the same for both salts. The different anions (chlorid and sulfat) have no great influence on the solubility (both very high), the vapour pressure (both extrem low), and the log Kow (both extrem low and negativ).
The second read-across approach between THPC and THPC-urea is based on the fact, that THPC is an impurity of the technical product THPC-urea. THPC is more reactive and more toxic than THPC-urea. A worst case scenario is created assuming that THPC-urea is completely reactive like THPC.
Furthermore, the oxidative degradation of THPC-urea, THPS and THPC results in the same main metabolite THPO, which is far less toxic than THPC-urea, THPS and THPC.
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