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EC number: 500-057-6 | CAS number: 27104-30-9
oral LD50 (rat) = 962 mg/kg bw (technical product)dermal LD50 (rat) > 2000 mg/kg bw (technical product)inhalation LC50: waived (exposure considerations)
An acute oral toxicity test (fixed dose method) according to OECD 420 was performed on the test item.
At 2000 mg/kg bw, one female rat was dead within 1 day after one single oral adiminstration. At 300 mg/kg bw, all five female rats tested survived the whole observation period of 14 days. The acute oral toxicity of the test item against female Wistar rats was estabhlished between 300 and 2000 mg/kg bw.
The test item was rankec into the GHS class 4 and into the EPA Category III ("Caution").
The test item was considered harmful if swallowed (R22) according to EU Commission Directive 2001/59/EC.
A acute dermal toxity test was performed on the test item AFLAMMIT SAP using Wistar rats.The test item was applied in one dose (2000 mg/kg bw) for 24 hours followed by a 14 day observation period.
No mortalities occured in male and female rats (five male and five female): LD50 > 2000 mg/kg bw.
Symptoms in the skin were observed only in female rats and were reversible after 11 day with the exeption of one female rat, which showed necrosis and scar on the treated skin at necropsy.
Pinprick-size haemorrhages were observed in 3 of male and 3 of 5 female rats by necropsy after 14 days.
AFLAMMIT SAP does not fulfill the criteria for classification adn labelling according to the Commission Directive 2001/59/EC.
AFLAMMIT SAP was ranked into the classes WHO II-III (moderately/slightly hazardous) and EPA III ("Caution").
Acute oral LD50 = 300 -2000 mg/kg bw AFLAMMIT SAP. Evidence from similar technical product: oral LD50=962 mg/kg bw (Tuffnell 1994).
Acute dermal LD50 > 2000 mg/kg bw AFLAMMIT SAP. Evidence from similar technical product: dermal LD50>2000 mg/kg bw (Tuffnell 1991).
oral LD50 (rat) = 962 mg/kg bw (technical product: 68% in water); substance is considered harmful if swallowed (Xn R22, GHS cat 4)
dermal LD 50 (rat) > 2000 mg/kg bw (technical product: 65-68% in water); substance is not hazardous (GHS cat 5)
inhalation LC50: waived (exposure considerations).
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