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EC number: 500-057-6 | CAS number: 27104-30-9
Tetrakis(hydroxymethyl) phosphonium chloride (THPC), oligomeric reaction products with urea is considered to be cytotoxic and corrosive by its intrinsic chemical reactivity (see IUCLID chapter7.3.1: Pascic 2006 + Gray, 2011). Test data with the polymer or the treated fabric are negative, but test results with structurally closely related compounds (THPC 80%, THPS 75% as well as Proban CC= 65% THPC-urea oligomere) are conclusive and sufficient for classification as skin sensitising.
read across from data/evidence based expert jugement: THPC is considered a skin sensitiser based on two other existing data: a 20% THPC aqueous solution was found positive for skin sensitisation Tuffnell (1992) and a 75% THPS aqueous solution was found positive for skin sensitisation (Guest, 1994) both by means of the GPMT (Magusson&Kligman).
The test substance has very low vapor pressure and no significant inhalation exposure is expected. The substance is an salt and manufactured and marketed in form of an aqueous solution. The use of this substance will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be unlikely to occur, and no inhalation test or resiratory sensitisation test was performed. No respiratory sensitisation did occur under intended conditions of handling and use (contiunous observation at workplaces in manufacturing site as well as in textile treatment plant).
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