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EC number: 907-640-8 | CAS number: -
Fischer-344 rats (10/sex/exposure) were exposed to 0, 15, 50 and 200 ppm (0, 91, 303 and 1212 mg/m3) of Dipropylene glycol monomethyl ether (colorless liquid) for 6 hr/day, 5 days /week for 13 weeks.
Rats were received frombreeding Laboratories. Rats were kept for acclimatization for 2 weeks period. At study initiation rats were of approximately 9 weeks old. Weight for rats at study initiation was approximately 190 -200 gms. Rats were housed 2/cage in stainless steel cages with wire bottoms. A standard laboratory diet (Purina Certified Laboratory Chow, Ralston Purina Co.) supplied to rats adlibitum except during exposure. Ad libitum water was supplied to rats except during exposure.
Monitored for effects included clinical observations, body weights, urinalysis rats only, hematology, blood chemistry and, necropsy, organ weights, gross pathology and histopathology.
All surviving animals underwent a gross necropsy on the day following their last exposure. Rats were deprived of food overnight prior to necropsy. Rats were anesthetized with methoxyflurane, and then decapitated. The trachea of all animals was clamped after anesthesia to prevent aspiration of blood during decapitation. Each animal was examined internally and externally for gross pathological changes. The heart, liver, kidneys, brain, thymus and testes were removed from each animal and weighed. Eyes of all animals were examined grossly using a microscope slide technique with fluorescent illumination. Representative portions of tissues were preserved in buffered 10 % formalin Liver samples from male rats (3/exposure group) were fixed in a phosphate buffered 2% gluteraldehyde 2 % and formalin 2 % solution, then routinely processed and embedded in EPON 812 resin for possible electron microscopy examination.
An extensive set of tissues, intended to include one or more sections of all tissues listed in table no. 1 were examined histologically from all animals in the control and high exposure groups. Nasal turbinates (rats only), liver, kidneys were also examined in the middle and low exposure groups. Tissues were processed by conventional techniques, stained with hematoxylin and eosin and evaluated by light microscopy
There were no DPGME exposure related adverse effects on body weights in rats during the 13 week study. There were no statistically significant differences from control body weight means in male and female rats..
There were no exposure related effects on any of the measured hematology parameters in either sex of rat. There were also no statistically significant differences from control means.
There were no exposure related effects on any of the measured clinical chemistry parameters in either sex of rat. The only statistically significant difference was a slight decrease in BUN in female rats exposed to 50 ppm, but this had no toxicological significance.
There were no apparent effects on any of the urinalysis parameters of male and female rats.
There were also no statistically significant differences in absolute or relative organ weights of rats exposed to DPGME, except for a slight decrease in mean relative liver weight of 50 ppm exposed males..
All gross and histopathologic observations were considered to be spontaneous changes of minimal severity which were not treatment related.
Based on the results of this study the NOAEL for dipropylene glycol methyl ether for inhalation exposure of Fischer-344 rats is 200 ppm.
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