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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
1962
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VI
Author:
Smyth and Carpenter
Year:
1962
Bibliographic source:
Amer. Ind. Hyg. Ass. J., 23:95-107

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
no
Test type:
other: Range-finding study
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rat
Strain:
other: albino
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Rats were exposed to a saturated air concentration of DPM for a period of 8 hours.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
not specified
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
Rats were exposed by whole body inhalation to a saturated atmosphere of DPM for the maximum exposure duration of 8 hours and observed for any mortalities after 14 days.
Statistics:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
mg/L air (nominal)
Exp. duration:
8 h
Remarks on result:
other: 14 day follow up
Mortality:
None
Clinical signs:
Not reported
Body weight:
Not reported
Gross pathology:
Not reported

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
DPM is not acutely toxic to rats by inhalation, at maximal achievable air concentrations.
Executive summary:

Six rats were exposed by whole body inhalation to air saturated with DPM vapour for a period of 8 hours, and followed for 14 days. No mortality was observed.