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Diss Factsheets
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EC number: 907-640-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study on methanol is relevant to the repeat dose toxicity of sodium methanolate. Humans are known to be more sensitive than rodents to the toxicity of methanol.
Data source
Reference
- Reference Type:
- other: USEPA study and IRIS summary
- Title:
- Rat oral subchronic toxicity study with methanol.
- Author:
- USEPA
- Year:
- 1 986
- Bibliographic source:
- United States Environmental Protection Agency, Office of Solid Waste, Washington, DC.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- GLP compliance:
- not specified
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Type:
- Constituent
- Details on test material:
- Not available
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No details were available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Rats were gavaged daily with 0, 100, 500, or 2500 mg/kg/day of methanol. Six weeks after dosing, 10 rats/sex/dose group were subjected to interim sacrifice while the remaining rats continued on the dosing regimen until the final sacrifice (90 days).
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 90-days
- Frequency of treatment:
- once/day
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
100 mg/kg/day
Basis:
actual ingested
- Remarks:
- Doses / Concentrations:
500 mg/kg/day
Basis:
actual ingested
- Remarks:
- Doses / Concentrations:
2500 mg/kg/day
Basis:
actual ingested
- No. of animals per sex per dose:
- 30
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Sprague-Dawley rats (30/sex/dose) were gavaged daily with 0, 100, 500, or 2500 mg/kg/day of methanol. Six weeks after dosing, 10 rats/sex/dose group were subjected to interim sacrifice while the remaining rats continued on the dosing regimen until the final sacrifice (90 days).
- Positive control:
- None
Examinations
- Observations and examinations performed and frequency:
- This study generated data on weekly body weights and food consumption, clinical signs of toxicity, ophthalmological evaluations, mortality, blood and urine chemistry, and gross and microscopic evaluations.
- Sacrifice and pathology:
- Gross and histopathology
- Other examinations:
- * opthalmic examination
* blood chemistry
* urinalysis - Statistics:
- Not described
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- no effects observed
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- There were no differences between dosed animals and controls in body weight gain, food consumption, gross or microscopic evaluations. Elevated levels of SGPT, SAP, and increased, but not statistically significant, liver weights in both male and female rats suggest possible treatment-related effects in rats dosed with 2500 mg methanol/kg/day despite the absence of supportive histopathologic lesions in the liver. Brain weights of both high-dose group males and females were significantly less than those of the control group. Based on these findings, 500 mg/kg/day of methanol is considered a NOAEL in rats.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day (actual dose received)
- Sex:
- male/female
- Basis for effect level:
- other: Brain weight decrease, elevated SGPT and SAP in absence of liver weight or histopathology
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Based on these findings, 500 mg/kg/day of methanol is considered a NOAEL in rats.
- Executive summary:
Sprague-Dawley rats (30/sex/dose) were gavaged daily with 0, 100, 500, or 2500 mg/kg/day of methanol. Six weeks after dosing, 10 rats/sex/dose group were subjected to interim sacrifice while the remaining rats continued on the dosing regimen until the final sacrifice (90 days).
There were no differences between dosed animals and controls in body weight gain, food consumption, gross or microscopic evaluations. Elevated levels of SGPT, SAP, and increased, but not statistically significant, liver weights in both male and female rats suggest possible treatment-related effects in rats dosed with 2500 mg methanol/kg/day despite the absence of supportive histopathologic lesions in the liver. Brain weights of both high-dose group males and females were significantly less than those of the control group.
Based on these findings, 500 mg/kg/day of methanol is considered a NOAEL in rats.
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