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EC number: 907-640-8
CAS number: -
Sodium Methanolate and
Methanol (See also Section 13 of this document):
(CAS No. 124-41-4) is the principle component of toxicological concern
for the glycol ether heavies. This
is due to the high pKa value for methanol (15.5), which results in the
rapid and complete conversion of the sodium methanolate to sodium
hydroxide and methanol upon reaction with water (OECD, 2006). The
toxicological properties of the sodium hydroxide become the prevalent
concern and dictate that the primary effects of exposure to the
methanolate will be corrosivity to the skin and mucous membranes (OECD,
corrosivity will sufficiently limit exposure to both the methanolate and
to free methanol.
Methanol is rapidly
absorbed by the oral, dermal and inhalation routes of exposure and
distributed rapidly and equally to all parts of the exposed organism. In
humans and primates, formate accumulation occurs at methanol doses in
excess of 500 mg/kg (OECD, 2006) and is associated with blindness and
CNS effects. An
equivalent dose of sodium methanolate would be 840 mg/kg (OECD,2006). Such
a dose of the methanolate is already acutely toxic (LD50values
in rats of 800 to 1687 mg/kg) resulting in pathological findings
associated with the severe corrosivity of the test material (OECD, 2006). It
is therefore highly unlikely that single or repeated exposures to
methanolate at non-corrosive levels would result in uptake of toxic
doses of methanol.
Tripropylene Glycol Methyl Ethers (See also Section 13 of this document):
The propylene glycol
ethers as a class are rapidly absorbed and distributed after oral
administration and less rapidly absorbed after dermal exposure but with
subsequent rapid distribution (OECD, 2003). Using
dipropylene glycol methyl ether (DPGME, CAS No. 34590-94-8) as example,
after oral administration approximately 60% of a14C DPGME
dose was excreted in urine, while 27% was eliminated as14CO2
within 48 hours. Less than 3% of the dose was recovered in feces,
indicating that the test material was effectively absorbed. Metabolites
identified in the urine include sulfate and glucuronide conjugates,
propylene and dipropylene glycol, propylene glycol methyl ether and some
unchanged DPGME. Tripropylene
glycol methyl ether (TPGME, CAS No. 25498-49-1) was similarly
metabolized to yield tripropylene glycol, dipropylene glycol and
propylene glycol as well as an oxidation product of dipropylene glycol,
dipropylene glycol monomethyl ether (DPGME), TPGME and the sulfate
conjugate of TPGME. Less
than 5 per cent of the dose was recovered as unchanged TPGME.
According to Venieret
al.(2004), DPGME is absorbed through full thickness human skin in
vitro at a moderate rate with a permeation coefficient of 0.11 cm-hr
short-term dermal absorption rates at 10 and 60 minutes have been
determined for DPGME using human abdominal skin from cadavers mounted in
anin vitrostatic diffusion cell model. The 10-minute absorption
rate was calculated to be 658.6 μg/cm2/h. The 60-minute
absorption rate was calculated to be 228.5 μg/cm2/h.
OECD (2003). Propylene
Glycol Ethers: SIDS Initial Assessment Report for SIAM 17, Arona, Italy,
11-14 November, 2003.
OECD (2006). Category
of Methanolates: SIDS Initial Assessment Report for SIAM 22, Paris,
France, 18-21 April, 2006.
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