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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
1962
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Older study, widely cited and used on many compounds for acute toxicity assessments. Article provides minimal but sufficient methodological detail.

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: List VI
Author:
Smyth, H.F. et al.
Year:
1962
Bibliographic source:
American Industrial Hygiene Association Journal, 23:95-107.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Remarks:
Study was done prior to GLP
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
None provided in the article

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
Age at start: 4-5 weeks
Weight: 90-120 g
Diet: Rockland rat diet, complete

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
Undiluted material was used, followed by 2-fold dilutions in water if lower doses were necessary.

Mortalities were noted during a 14-day follow up period.
Doses:
Not specified
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
Animals were dosed once by oral gavage with undiluted test material, and aqueous dilutions if needed. The LD50 was calculated based on total mortalities observed within a 14-day follow up period.
Statistics:
LD50 was calculated using the method of Weil (Biometrics 8:249, 1952).

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
5.66 mL/kg bw
Remarks on result:
other: 5380 mg/kg based on a specific gravity of 0.951

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
DIpropylene glycol monomethyl ether (DPM) was administered by single oral gavage to groups of 5 male rats, and mortality followed for 14 days. The calculated LD50 was 5.66 mL/kg (5380 mg/kg).