Registration Dossier
Registration Dossier
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EC number: 203-897-9 | CAS number: 111-70-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Contribution à l'étude toxicologique de l'alcool n-heptylique
- Author:
- R. Truhaut
- Year:
- 1 974
- Bibliographic source:
- Archive des maladies Professionnelles de Medecine du Travail. 35, 4-5, Avril-Mai
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Heptan-1-ol
- EC Number:
- 203-897-9
- EC Name:
- Heptan-1-ol
- Cas Number:
- 111-70-6
- Molecular formula:
- C7H16O
- IUPAC Name:
- heptan-1-ol
- Details on test material:
- Purity>97%
- Name of test material (as cited in study report):n-heptanol-1
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: non exposed eye
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 1, 2, 3, 4 and 7 days
- Number of animals or in vitro replicates:
- 6 rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.16
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.94
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.22
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
Applicant's summary and conclusion
- Interpretation of results:
- Category II
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- n-heptanol-1 is considered as irritating to eyes.
- Executive summary:
The potential of n-heptanol-1 to induce ocular irritation was evaluated in rabbits according to OECD (No. 405) guideline. A single dose of 0.1mL of the undiluted test item was instilled into the conjunctival sac of the eye of 6 rabbits. The eyes were not rinsed after administration of the test item.
Ocular reactions were observed approximately 1 hour, 24, 48 and 72 hours after the administration. Mean scores calculated over 24, 48 and 72 hours were 0.22 for chemosis, 0.94 for redness of the conjunctiva, 0.0 for iris lesions and 1.16 for corneal opacity. We observed that the test item indiced slght opcity of the cornea with a slght irritation of the conjonctive. The irritation is at maximum at 72 hours and reverse progressively. 4/6 rabbits did not present signs of irritation after 7 days. Under these experimental conditions, n-heptanol-1 was irritant when administered by ocular route to rabbits.
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