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Partition coefficient

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Description of key information

The objective of this study was to determine the Partition Coefficient of the test item n-heptanol applying the procedure described in the OECD Guideline 117 Partition Coefficient (n-octanollwater), HPLC Method. The 3 replicate determinations show that for the Partition Coefficient of n-heptanol, the log Pow mean value is 2.2.

Key value for chemical safety assessment

Log Kow (Log Pow):
2.2
at the temperature of:
20 °C

Additional information

The objective of this study was to determine the Partition Coefficient of the test item n-heptanol applying the procedure described in the OECD Guideline 117 Partition Coefficient (n-octanollwater), HPLC Method. The 3 replicate determinations (see table hereafter) show that for the Partition Coefficient of n-heptanol, the log Pow mean value is 2.2.

 

Partition Coefficient

Log Pow

Test 1

2.2

Test 2

2.2

Test 3

2.2

Mean Value

2.2

Based on this result it can be concluded that n-heptanol is characterized by a low potential of bioaccumulation and adsorption.

The objectives of the study of Veith (1979) whose results are quoted in the publication of Broderius & Kahl (1985) were to demonstrate the relationship of log P and the high-pressure liquid chromatography (HPLC) reverse-phase retention time using a wide variety of industrial chemicals, and to develop a method for estimating log P by using HPLC. The partition coefficient of heptan-1-ol was evaluated in this study performed according to a protocol similar to OECD testing guideline 117. The partition coefficient of heptan-1-ol was estimated at 2.49. This result comes to reinforce the fact that heptan-1-ol is characterized by a low potential of bioaccumulation and adsorption.