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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Description of key information

Two academic studies on algae were available (Bringmann et al.,1978 ; Sloof et al., 1983) but it was proposed to perform a study carried out according to present standards of quality to get a more reliable datum: the acute toxicity of n-HEPTANOL was evaluated with Pseudokirschneriella subcapitata according to OECD testing guideline 201 and following GLP requirements (Gancet et al., 2012). However, this study was disregarded because of high variability in control algae growth rate that induces significant methodological deficiencies (Klimisch 3b). Nevertheless, an OECD 201 GLP study meeting all validity criteria was found (Mitsubishi, 2001). EC50 =32.7 mg/L and EC10 = 10.4 mg/L.

Key value for chemical safety assessment

EC50/LC50 for freshwater algae:
32.7 mg/L
EC10, LC10 or NOEC for freshwater algae:
10.4 mg/L

Additional information

Two academic studies on algae were available and came from experiments carried out by Bringmann et al. and published in 1978 on Scenedesmus quadricauda and Sloof et al 1983, on Pseudokirschneriella. Only NOECs (or equivalent TT) were provided.

For Bringmann et al, several substances reported in these articles have been tested several times with significantly different results, thus, there are doubt about reliability of these results. For Sloof et al, very few details are given on the experiment and calculation. Gancet (2012) was diregarded.

Finally, one acceptable fully reported OECD 201 GLP compliant study is available (Mitsubishi, 2001). EC50 = 32.7 mg/L and EC10 = 10.4 mg/L