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Description of key information

There are an acute oral and dermal toxicity study performed in rats and rabbits, respectively (R. Truhaut, 1974). An acute inhalation study in rats was perfomed. The studies designs were comparable to respective guideline studies.
LD50 oral (rats) : approx 5500 mg/kg
LD50 dermal (rabbits) >2000 mg/kg
LC0 (rats)=7.4 mg/m3

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
5 500 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
discriminating conc.
7.4 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
discriminating dose
2 000 mg/kg bw

Additional information

Acute oral toxicity (R, Truhaut, 1974)

The acute oral toxicity study was evaluated in rats for n-heptanol-1. The acute toxicity was considered low for each of the males and the females. During the necropsy examinaqtion, signs of irritation were recorded for the lung parenchyma for the male rat. Indeed, acute edema of the lung was recorded for the animals found dead few hours after test item administration, this was substantiated by inflamation of the lung alveolar and hemosiderin deposits. In the males rats, congestion and inflammation of the lung were associated with lesions in the lungs but the incidence was not dose-related. In the females rats, kidney dilatation was observed at the highest dose-levels. No other effects were observed on the sampled organs.

Acute inhalation toxicity (R. Truhaut, 1974)

The test item, n-heptanol-1 was exposed by inhalatation to 10 males and 10 females rats at the maximum saturated concentration via asingle whole body inhlation exposure during 4 hours. Animals were submitted to a 2 week observation period.

No mortality was recorded in any animal. No signs of narcosis were observed nor abnormal behaviour. The histopathological examination of the sample organs (brain, lung, heart, liver, pancreas, bladder, kidneys, ovaries and testes) has revealed no treatement related changes. At the maximum vapour saturated concentration, no mortality was recorded after a single exposure during 4 hours. The LC0 was estimated at 7.4 mg/m3.

Acute dermal toxicity (R. Truhaut, 1974)

The acute dermal toxicity of n-heptanol was evaluated in rabbits . The test item was applied to the skin of rabbits (6 animals/dose) at the dose-levels of 20.5, 32.8 and 41.0 g/ animal for 24 hours. Animals were then observed during 14 days for mortality, clinical signs, effects on body weight. Half of the rats were necropsied after 2 weeks and the other half after 6 weeks. 2/6 animals died at the dose-level of 32.8 g/animal (approx 11.7 g/kg) and 4/6 animals died at 2.7 g/animal (equivalent 14.6 g/kg). Lesions of the skin (caustic) and the brain were recorded at histopathological examination.

The LD 50 by dermal route was higher than 2 g/kg.

Justification for classification or non-classification

According to REGULATION (EC) No 1272-2008:

Acute oral toxicity:

LD 50 > 5500 mg/kg. Not classified

Acute inhalation toxicity:

No mortality was recorded at the maximum saturated dose. The approximated calculated LC0 was set at 7.4 mg/m3 (7455 mg/l). No classification is warranted based on the available data.

Acute dermal toxicity:

No classification is warranted based on the available data. LD50>2000 mg/kg.