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Partition coefficient

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Description of key information

2-isocyanatoethyl methacrylate: log Pow = 1.72 (KOWWIN v.1.68)
hydrolysis products: log Pow = 1.24 and log Pow = 0.3 (KOWWIN v.1.68)

Key value for chemical safety assessment

Log Kow (Log Pow):
1.72

Additional information

2-isocyanatoethyl methacrylate is hydrolytically unstable at pH 4, 7 and 9 (half-life is < 10 min at 50 °C) and the testing of the substance is not possible. Therefore the log Pow of the substance 2-isocyanatoethyl methacrylate (CAS 30674-80-7) was estimated by a calculation method using a computer program KOWWIN v1.68 (logPow=1.72). Additional calculation with Pallas 3.1.1.2. (log Pow=1.08) supports the KOWWIN v1.68 value, which is taken as a key value for chemical safety assessment.

The log Pow of two hydrolysis products was calculated with KOWWIN v1.68:

log Pow=0.3 for 2-aminoethyl methacrylate and

log Pow=1.24 for 2-[((2-[(2-methylacryloyl)oxy]ethyl)carbamoyl) amino]ethy-2-methylprop-2-enoate).