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EC number: 433-480-9 | CAS number: 623-53-0
A total of two key studies have been identified as having assessed acute toxicity in the rat following oral and inhalatory exposure. A supporting oral toxicity study using an analogue chemical (diethyl carbonate) as the test substance is also available and indicates minimal toxicologic effects.
Acute oral toxicity:
The key study followed the OECD 401 guideline and was GLP-compliant. Five male and five female rats were used for each dose group and observed for 14 days post-exposure. The main clinical findings were ataxia, hunched posture, lethargy, reduced respiratory rate and laboured respiration. The LD50 was determined to be >5000 mg/kg. A supporting study using a chemical analogue (diethyl carbonate) as the test material confirmed the findings of the key study of low oral toxicity and gave a LD50 of >15000 mg/kg.
Acute inhalation toxicity:
The key study followed the OECD 403 guideline and was GLP-compliant. A limit test using five male and five female rats was conducted with nose only exposure for 4 hours. Test animals were observed over a 14-day period and surviving animals were sacrificed and necropsied. Clinical effects during exposure include increase in respiratory rate, wet fur and an isolated instance of laboured respiration. No macroscopic abnormalities were observed at necropsy. The LC50 was determined to be >17.6 mg/l (measured).
Acute dermal toxicity:
This endpoint has been waived as the main route of exposure will be predominantly via the inhalation route.
Based on the results of the key study (oral LD50 >5000 mg/kg) ethylmethylcarbonate is:
- Not classified for the oral route in accordance with the criteria given in Regulation 1272/2008 (EU CLP GHS).
- Not classified for the oral route in accordance with the criteria given in Directive 67/548/EEC (DSD).
Based on the results of the key study (inhalation LC50 > 17.6 mg/l) ethylmethylcarbonate is:
- Not classified for the inhalation route in accordance with the criteria given in Regulation 1272/2008 (EU CLP GHS).
- Not classified for the inhalation route in accordance with the criteria given in Directive 67/548/EEC.
Although there is a case for classification of the inhalation route, the findings of the key study indicate that no treatment-related mortalities were observed and in addition no significant clinical effects were observed (clinical effects that were observed were mainly due to restraint procedures - these were transient and disappeared by day 1).
No information available for classification.
No classification for acute toxicity via the oral, inhalation or dermal route is applied to ethylmethylcarbonate in Annex VI of the CLP Regulation No.1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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