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EC number: 433-480-9
CAS number: 623-53-0
A guinea pig maximisation test was conducted using Dunkin Hartley strain
guinea pigs to assess the sensitising potential of ethyl methyl
carbonate. For the first induction (intradermal) a 1%
v/v test substance concentration in arachis oil BP was used and the
second (topical) induction was used undiluted as supplied. The challenge
dose (25% and 50% in arachis oil BP) was applied 21 days after the first
induction treatment, via topical application to the lateral flanks.
Reactions were scored 24 and 48 hours after removal of the challenge
patch: no adverse skin reactions were seen in any test or negative
control animals. Based on the results of this study, ethyl methyl
carbonate is not considered to be a skin sensitiser.
Based on the results of the sensitisation key study (Guinea pig
maximisation test for skin sensitisation), ethyl methyl carbonate is not
classified as a skin sensitiser under:
- Directive 67/548/EEC criteria
- Regulation 1272/2008 (EU CLP GHS) criteria
No classification for sensitisation is applied to ethyl methyl carbonate
in Annex VI of the CLP Regulation No.1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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