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EC number: 433-480-9
CAS number: 623-53-0
Two studies have been identified as having assessed the skin irritation/corrosion potential and eye irritation potential of ethyl methyl carbonate. Both studies have determined that ethyl methyl carbonate is not irritating to the skin or eyes. Respiratory irritation was determined from an acute inhalation toxicity study.
The test substance was applied to intact skin of rabbits with a
semi-occlusive wrap. One treated animal showed slight erythema one hour
post patch removal. Another animal also presented with slight erythema
at 24 and 48 hours after patch removal. All irritant effects observed
were resolved by the end of the 72 hour observation period. Based on the
findings of this study, ethyl methyl carbonate is considered to be not
irritating to the skin.
0.1ml of undiluted test material was applied to six rabbit eyes followed
by examinations at 1, 24, 48 and 72 hours following treatment. No
corneal effects were observed during the study. Iridial inflammation was
observed in one treated eye 1 hour after treatment, but no other iridial
effects were noted. Minimal to moderate conjunctival irritation was
observed in all treated eyes an hour after treatment. In one eye
conjunctival redness persisted to the 24 -hour observation. All treated
eyes appeared normal 24 -48 hours post-treatment. Mean overall scores at
1, 24, 48, and 72 hours were 4.8, 0.3, 0 and 0 respectively. Based on
the findings of this study, ethyl methyl carbonate is not considered to
be irritating to the eyes.
Respiratory irritation was determined from an acute inhalation toxicity
study. The key study followed the OECD 403 guideline and was
GLP-compliant. A limit test using five male and five female rats was
conducted with nose only exposure for 4 hours. Test animals were
observed over a 14-day period and surviving animals were sacrificed and
necropsied. The respiratory tract was macroscopically examined for signs
of irritancy or local toxicity. No significant clinical effects occurred
and no macroscopic effects were observed. Ethyl methyl carbonate is not
considered to be a respiratory irritant.
Based on the results of the skin corrosion/irritation study and eye
irritation study, ethyl methyl carbonate is not classified as a skin,
eye or respiratory irritant under:
- Directive 67/548/EEC criteria
- Regulation 1272/2008 (EU CLP GHS) criteria
No classification for skin irritation/corrosion, eye irritation or
respiratory irritation is applied to ethyl methyl carbonate in Annex VI
of the CLP Regulation No.1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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