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Partition coefficient

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Description of key information

Octanol-water partition coefficient: Pow=2.20, log Pow=0.343 at pH=2.9±0.1 and 22°C (study performed at pH=2.9±0.1), and Pow=0.00481, log Pow=-2.32 at pH=7 and 22°C (value calculated)

Key value for chemical safety assessment

Log Kow (Log Pow):
-2.3
at the temperature of:
22 °C

Additional information

The study performed in experimental laboratory (Fox, 2009, Harlan), dedicated to estimate the partition coefficient of the test material 3-mercaptopropionic acid, has been chosen as a key study. The octanol-water partition coefficient has been determined to be Pow=2.20, log Pow=0.343 at pH=2.9±0.1 and 22°C (study performed at pH=2.9±0.1), and Pow=0.00481, log Pow=-2.32 at pH=7 and 22°C (value calculated), by using the shake-flask method, according to Method A8 Partition Coefficient of Council Regulation (EC) No 440/2008 of 30 May 2008 and Method 107 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

The other two reported studies (Hansch et al., 1995 and Leo, 1995) are supporting studies. They reported the following values of log Pow: 0.09 and 0.43, respectively. The information given there is not complete (no information about temperature and pH) but qualitatively supports the key study (log Pow<3).