Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: QSAR estimations from dermal absorption tend to be conservative; however, they are not formally validated
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: database
Title:
Danish QSAR Database
Author:
Anonymous
Bibliographic source:
http://ecbqsar.jrc.it/

Materials and methods

Principles of method if other than guideline:
The Danish QSAR Database reports DERMWINv.2 calculations. These are based on the Guy & Potts formula (GUY R.H. AND POTTS R.O., 1992. Structure-Permeability Relationships in Percutaneous absorption. J. Pharm. Sci.. 81: 603-604).

Test material

Constituent 1
Chemical structure
Reference substance name:
3-mercaptopropionic acid
EC Number:
203-537-0
EC Name:
3-mercaptopropionic acid
Cas Number:
107-96-0
Molecular formula:
C3H6O2S
IUPAC Name:
3-sulfanylpropanoic acid

Results and discussion

Applicant's summary and conclusion

Conclusions:
MPA is predicted to have significant dermal absorption potential. SInce MPA is highly corrosive, dermal exposure must be prevented by suitable protective garment.