Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 203-537-0 | CAS number: 107-96-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
- Category name:
- 3-MPA family, simple esters
Justifications and discussions
- Category definition:
- 3-Mercaptopropionic acid, and its esters
- Category description:
- This category includes 3-MPA and esters of 3-MPA with mono-alcohols differing in C-chain length (C1 – C18) and degree of branching.
- Category rationale:
- This category includes 3-MPA and esters of 3-MPA with mono-alcohols differing in C-chain length (C1 – C18) and degree of branching. BuMP and ODMP contain a linear alcohol side chain, whereas EHMP is manufactured from 2-ethylhexanol, and iOMP and iC13MP contain branched site chains with overall a low degree of branching (mostly methyl-branches).
3-MPA as free acid is included in this category, since it is formed by ester hydrolysis and is therefore the primary common metabolite in this category.
The category members follow structurally related trends in physical chemical properties (water solubility, log Kow, and vapour pressure). The available acute oral toxicity studies also revealed a trend towards less toxicity with increasing carbon chain length. All members share a common chemical reactivity, metabolism pathways and biological properties that enable interpolation and read across between category members for systemic toxicity endpoints.
Esters with poly-alcohols are assigned to a separate category since they contain more than one free sulfhydryl function.
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