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Administrative data

Description of key information

MPA has shown skin corrosivity in vitro and in vivo. It caused irreversible cornea damage in one rabbit. Rats exposed to an MPA aerosol exhibited clinical signs and necropsy findings indicative of respiratory irritation.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Effects on skin irritation/corrosion: highly corrosive

Effects on eye irritation: corrosive

Effects on respiratory irritation: irritating

Justification for classification or non-classification

MPA has to be classified as strongly corrosive, based on the in-vitro results that were interpreted along the lines of ECVAM recommendations.

EU classification: C, R35-37. Causes severe burns. Irritating to respiratory system.

GHS classification: Danger. Corrosive. Cat.1A. STOT SE3; H314 Causes severe skin burns and eye damage. H335: May cause respiratory irritation.