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EC number: 204-688-5 | CAS number: 124-19-6
A valid study for acute toxicity to rainbow trout is available for the analogue substance, Decanal. The 96 hr LC50 was determined to be 1.45 mg/L (based on Geometric Mean Measured Concentrations)and is considered a reliable estimate for the target substance, nonanal..
A valid study is available for the analogue substance, decanal. It is a GLP compliant study conducted in compliance with agreed protocols, with no or minor deviations from the standard test. Important considerations for the use of read-across are:
i) Nonanal (the target chemical) is structurally similar to decanal (the source substance). Both are linear aliphatic mono-aldehydes. The only structural difference is the chain length ,C9 and C10 respectively.
ii) Both substances are expected to act via the same mode of action for aquatic toxicity. Characterization using the OECD QSAR Toolbox shows that the 5 primary profilers relevant to acute aquatic toxicity are identical
iii) There are no impurities that are expected to affect the ecotoxicological properties of the source and target substance
iv) Uptake / lipophilicity (as modelled by log Kow) is a known determinant of the toxicity in aquatic organisms. Nonanal and decanal, which vary only by one carbon atom in chain length, have similar measured log Kow values of 3.4 and 3.8 respectively, and therefore the strength of aquatic toxicity for the two substances is expected to be similar.
v) Both chemicals have been tested for ready biodegradability, acute toxicity to daphnia, and toxicity to microorganisms. Both chemicals gave similar results.
Based on the above, read-across is justified. Furthermore, the 48-h EC50 daphnia results for both substances, the algae 72h ErC50 for the target and the fish 96h LC50 for the source substance are in the same classification band (1-10mg/L) and as such the read-across is considered adequate for the purpose of classification and labelling and/or risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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